Meet Some of the Physicians
and Cervical Spinal Cord
Injury Patients in the
AST-OPC1 Clinical Trial
 

Careers at Asterias Biotherapeutics

Asterias Biotherapeutics is a growing and dynamic biotechnology company focusing in the cutting edge field of regenerative medicine. We are committed to treat diseases where existing therapies do too little or do not exist at all. Both our corporate center and R&D facilities are co-located in the San Francisco Bay Area, one of the hottest regions for biopharma in the U.S. Our active development programs evolve continuously, so we are always looking for high caliber talent with biotech experience to join our team. Asterias offers competitive salaries with comprehensive benefits.

Please explore available opportunities to join our team in current job postings below:

  •   
      Product & Process Development Scientist
    Full Time
    Fremont, CA 94555

    Department
    Product Development (PD)
    Full Time - Fremont, CA 94555

    Position Description

    The Product & Process Development Scientist position will focus on downstream process development as well as working with device engineering personnel within and external to the company.

    As a member of Process Development, this position will facilitate testing and implementation of future production processes as well as process conversions and technology integration to allow a scaled process transfer for either in-house or outsourced production.

    Product Development engineering responsibilities include interfacing with Process Development team members, Quality teams, as well as supervision of the internal device engineer and external suppliers to define, develop, test, and deliver process and product engineering solutions around cell therapy drug product delivery; cell isolation / depletion; filtration; closed system scale-up implementation, formulation selection, primary/secondary packaging, and automated vial filling technologies.

    The position will work alongside Process Development, Manufacturing, Quality, and Clinical staff to direct process and product improvement targets and optimize process implementation. This individual will also participate in corporate development presentations and publications as well as provide technical guidance and input for timely patent filings and prosecutions. This position will assist in defining resource requirements, develop budgets, manage facility needs and create timelines.

    Summary of essential job functions

    • Maintain and expand expertise in cell therapy and immunotherapy technologies, production, formulation, and delivery
    • Perform/direct scale up and certification of cell isolation / depletion technologies
    • Oversee new therapeutic candidate administration device design, sourcing, release and training
    • Perform/direct improvement of existing processes through closed system and scale-up development
    • Lead/Assist in formulation development, cryopreservation optimizations and efforts
    • Direct/Oversee product engineer's efforts including product device design, creation, and implementation
    • Participate in current drug product delivery and administration optimization efforts
    • Integrate QBD guidelines into new processes
    • Generate publications on process improvements and technology integration
    • Lead and coordinate staff career development efforts
    • Assist/lead product and engineering device related FMEA, as necessary
    • Participate in Asterias' multidisciplinary project teams to help oversee development activities
    • Coordinate and write technical reports on key development findings
    • Support regulatory experts to prepare, file and maintain appropriate regulatory body documents
    • Assist project management to determine development activities, timelines and resource needs to meet corporate goals
    • As necessary, assist corporate development to support contracts and other legal documents to execute workplans and projects
    • As necessary, work with Asterias' legal professionals to file and prosecute Asterias' intellectual property

    Minimum requirements

    • Ph.D.in Life Sciences, Chemical, Mechanical or Bio-Engineering
    • 3 or more years corporate experience within pharmaceutical or biotechnology
    • Experience in process development of cell-based therapy or immunotherapy cell culture required
    • Experience in hESC culture, dendritic cell, and CMC filings desired
    • Strong oral and verbal communications skills with a collegial personality
    • A proven record of innovation
    • Ability to communicate effectively with a diverse range of scientists, physicians, engineers, regulatory specialists and business
    • Thrive and succeed in a team-oriented entrepreneurial environment

    Abilities Required

    Computer literacy with standard corporate (MS) software required
    Familiarity with JMP® DOE and statistical software desired
    Up to 25% travel required, some international

    Disclaimer

    The above statements are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time, as needed.

    Please send your resume to our hiring department (cover letter optional) email jobs@asteriasbio.com

    Apply using webmail: Gmail / AOL / Yahoo / Outlook

  •   
      Senior Research Associate, Process Development
    Full Time
    Fremont, CA 94555

    Department
    Product Development (PD)
    Full Time - Fremont, CA 94555

    Position Description
    The Sr. Research Associate position will work with all or select technology and process development efforts within the company. Development will facilitate testing and implementation of future production processes and technologies and is responsible for process conversions and technology integration to allow scale appropriate process transfer to either in-house or outsourced production. This position will liaise with research, production, engineering, and analytical technologies to foster effective communication, technology transfer and achievement of corporate goals between groups. The position will work alongside PD and Research staff to support process improvements targets and optimize process implementation. This position will participate in daily operations of development laboratories. This individual will assist in corporate development presentations and publications.

    Responsibilities

    • iExecute experiments directed towards scale-up process development and optimization using undifferentiated human embryonic stem cells: including but not limited to regular passaging of cells, thawing and freezing cell lines, cell banking and processing samples.
    • Optimize formulations & final processing schemes for final delivery to patients.
    • Solve technical issues and evaluate and implement new technology/instrumentation based on scientific literature and industry trends as well as requirements for GMP production.
    • Generate technical documents (protocols, technical reports, summaries, process investigations, SOPs and batch records).
    • Generate, manage, evaluate, and maintain complete and accurate laboratory documentation and critical data in electronic files in a highly organized manner.
    • Collaborate with cross-functional teams i.e., Research, Quality, Production and Analytical Technologies.
    • Support process sampling plan to monitor process development activities and optimization through adequate sample archives.
    • Present and discuss experimental findings in lab and departmental meetings.
    • Train new hires on the process of culturing uhESC and differentiation into different products.

    Requirements

    • BS or MS in Biology, Biochemistry, Chemical Engineering/Biological Engineering or related field with at least 5-8 years relevant corporate experience at pharmaceutical or biotechnology company.
    • Experience in cell-based therapy culture and development.
    • Prior experience in bioreactor operation or development a plus.
    • A proven record of innovation, excellent laboratory, data analysis, and critical thinking skills required.
    • Strong communication abilities (verbal, written, interpersonal).
    • Excellent time management skills (schedules, timelines, task prioritization) and the ability to adapt to changing priorities.
    • Excellent multi-tasking and problem-solving skills; solution-oriented; self-motivated.
    • Flexible in regards to weekends and holiday work schedule.
    • Thrive and succeed in a team-oriented entrepreneurial environment.
    • Computer literacy with standard corporate (MS) required.
    • Familiarity with JMP® DOE and statistical software desired.

    Please send your resume to our hiring department (cover letter optional) email jobs@asteriasbio.com

    Apply using webmail: Gmail / AOL / Yahoo / Outlook

  •   
      Product Development Associate
    Full Time
    Fremont, CA 94555

    Department
    Product Development (PD)
    Full Time - Fremont, CA 94555

    Position Description
    The Research Associate position will work with all or select technology and process development efforts within the company. Development will facilitate testing and implementation of future production processes and technologies and is responsible for process conversions and technology integration to allow the scale of appropriate process transfer to either in-house or outsourced production. This position will liaise with research, production, engineering, and analytical technologies to foster effective communication, technology transfer and achievement of corporate goals between groups. The position will work alongside PD and Research staff to support process improvement targets and optimize process implementation. This position will participate in daily operations of development laboratories. This individual will support efforts around corporate development presentations and publications.

    Responsibilities

    • Assists in experiments directed towards process development and optimization using undifferentiated human embryonic stem cells: including but not limited to preparation of cell culture raw materials, monitoring, sampling and documenting of cell culture performance, regular passaging of cells, thawing and freezing cell lines, cell banking and processing samples.
    • Generate, manage, evaluate, and maintain complete and accurate laboratory documentation and critical data in electronic files in a highly organized manner.
    • Operates, maintains, and troubleshoots lab and cell culture equipment
    • Draft and review technical documents (protocols, technical reports, summaries, process investigations, SOPs and batch records).
    • Collaborate with cross-functional teams i.e., Research, Quality, Production and Analytical Technologies.
    • Support process sampling plan to monitor process development activities and optimization through adequate sample archives
    • Support laboratory operations and logistics

    Requirements

    • BS (with 2+ years’ experience) or MS (with 0+ years’ experience) in Biology, Biochemistry, Chemical Engineering/Biological Engineering or related field of at pharmaceutical or biotechnology company .
    • Experience in aseptic mammalian cell culture handling experience, required
    • Experience in cell-based therapy culture and/or development a plus
    • A proven record of excellent laboratory, data analysis, and critical thinking skills required
    • Strong communication abilities (verbal, written, interpersonal).
    • Excellent time management skills (schedules, timelines, task prioritization) and the ability to adapt to changing priorities.
    • Excellent multi-tasking and problem-solving skills; solution-oriented; self-motivated. 
    • Flexible in regards to weekends and holiday work schedule.
    • Energetic, positive, hardworking.
    • Thrive and succeed in a team-oriented entrepreneurial environment

    Abilities required

    • Computer literacy with standard corporate (MS) required

    Please send your resume to our hiring department (cover letter optional) email jobs@asteriasbio.com

    Apply using webmail: Gmail / AOL / Yahoo / Outlook

Asterias Biotherapeutics Tel: (510) 456-3800