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Careers at Asterias Biotherapeutics

Asterias Biotherapeutics is a growing and dynamic biotechnology company focusing in the cutting edge field of regenerative medicine. We are committed to treat diseases where existing therapies do too little or do not exist at all. Both our corporate center and R&D facilities are co-located in the San Francisco Bay Area, one of the hottest regions for biopharma in the U.S. Our active development programs evolve continuously, so we are always looking for high caliber talent with biotech experience to join our team. Asterias offers competitive salaries with comprehensive benefits.

Please explore available opportunities to join our team in current job postings below:

  •   
    Senior Scientist, Immunology
    Full Time
    Fremont, CA

    Title: Senior Scientist, Immunology

    Department: Product Development

    Reports to: Executive Director, Product Development

    Position Description:

    Asterias Biotherapeutics is seeking a talented and dynamic scientist for a Senior Scientist position in the Regenerative Medicine and Immune-oncology Product Development team. This individual will be directly responsible for executing experiments and leading ongoing efforts in the discovery and development of novel stem cell therapies for advancement into the clinic. The position will actively support projects both in early and late stage development across multidisciplinary teams.

    Summary of Essential Job Functions:

    • Drive discovery and translational efforts to support projects aimed at optimizing the differentiation of human pluripotent stem cells into desired cell types
    • Manage and identify key external collaborations that would enhance decisions on projects and/or yield new target indications
    • Lead efforts for development of in vitro cell-based assays to characterize the phenotype and potency of candidate cell therapies
    • Contribute to the hands-on development and performance of immune-monitoring assays for patients receiving candidate cell therapies
    • Apply knowledge and know-how internally on project teams as well as represent the company externally
    • Lead identification and testing of novel scientific /technical opportunities
    • Design and execute experimental plans, provide interpretation, troubleshoot and suggest next steps
    • Maintain laboratory notebooks in a professional, and accurate manner
    • Interact and collaborate with members of all other departments at Asterias, including Analytical Technologies, Process Development, and Clinical Operations
    • Prepare study reports and presentations for group meetings, conferences, publications and regulatory filings

    Minimum Requirements

    • Ph.D. degree with 5 or more years post-graduate experience related to the field of immune-oncology and stem cell biology
    • Preference will be given to candidates with a strong background in T cell immunology and dendritic cell biology
    • Proven record of applicable immunology or immune-oncology relevant publications
    • Proficient cell culture techniques of human cell lines, pluripotent stem cells, and primary cells
    • Hands-on experience with isolating, culturing, and expanding antigen-specific lymphocytes from human whole blood
    • Immunological techniques (Multi-color flow cytometry, ELISpot, and ELISA), Cell-based immunoassays (MLR, CTL assays)
    • Basic molecular biology techniques (DNA/RNA preparation, qPCR, cloning)
    • Requires up to 5-10% international travel
    • Computer skills in Excel, PowerPoint, word processing, and data presentation
    • Excellent organizational, communication, and written skills

    Disclaimer:

    The above statements are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time, as needed.

    Please send your resume to our hiring department (cover letter optional) email jobs@asteriasbio.com

    Apply using webmail: Gmail / AOL / Yahoo / Outlook

  •   
    Lead Manufacturing Associate
    Full Time
    Fremont, CA

    Title: Lead Manufacturing Associate

    Department: Manufacturing

    Reports to: Director, Technical Operations

    Position Description:

    We are seeking a highly motivated Lead Manufacturing Associate with experience in cGMP manufacturing and cell culture. This position is a lead position within the group and will provide technical expertise to other employees. This individual will perform a variety of procedures in a manufacturing environment in compliance with cGMP regulations to manufacture cell therapy products for use in human clinical trials.

    Responsibilities:

    • Produce cell therapy products using undifferentiated human embryonic stem cells in accordance with the manufacturing procedures, SOPs, and approved protocols in cGMP manufacturing environment
    • Write and/or revise master production records, SOPs, training materials, protocols, reports, and other required documentation
    • Provide support for commissioning and validation activities in addition to other facility start-up activities, as needed
    • Train staff in processing methods, aseptic technique and cGMP clean room operations
    • Organize, coordinate and lead production activities and ensure execution of processes in production while strictly adhering to cGMP regulations, environmental health and safety guidelines, and any other related regulations which could apply
    • Review batch production records for completeness, accuracy, and to ensure cGMPs and Good Documentation Practices are followed
    • Troubleshoot technical process and equipment problems
    • Collaborate with cross-functional teams i.e., Quality, Facilities, Product Development, and Analytical Technologies
    • Perform additional job related duties as required

    Requirements

    • BS in Biology/Chemistry/Life Sciences or related field with at least 5-8 years relevant cGMP manufacturing experience in Pharmaceutical/Biotech industry is required. Aseptic manufacturing experience is highly desired
    • Mammalian cell culture experience is required
    • Must have proven aseptic technique and be capable of training individuals in aseptic technique
    • Experience writing standard operating procedures and other cGMP documentation
    • Experience writing investigation, deviation and change control documentation
    • Ability to troubleshoot and problem solve in order to initiate, execute, and monitor corrective action
    • Excellent time management skills (schedules, timelines, task prioritization) and the ability to adapt to changing priorities
    • Excellent multi-tasking and problem-solving skills; solution-oriented; self-motivated
    • Must be able to work weekends and holidays as required
    • Excellent oral and written communications skills and a collegial personality
    • Thrives and succeeds in a team-oriented environment
    • Computer literacy including fluency with Microsoft Word, Excel, Outlook
    • Ability to sit or stand for long periods of time, and ability to lift 25-30 lbs

    Disclaimer:

    The above statements are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time, as needed.

    Please send your resume to our hiring department (cover letter optional) email jobs@asteriasbio.com

    Apply using webmail: Gmail / AOL / Yahoo / Outlook

  •   
    Manufacturing Associate
    Full Time
    Fremont, CA

    Title: Manufacturing Associate

    Department: Manufacturing

    Reports to: Director, Technical Operations

    Position Description:

    We are seeking a highly motivated Manufacturing Associate with experience in cGMP manufacturing and cell culture. This individual will perform a variety of procedures in a manufacturing environment in compliance with cGMP regulations to manufacture cell therapy products for use in human clinical trials.

    Responsibilities:

    • Produce cell therapy products using undifferentiated human embryonic stem cells in accordance with the manufacturing procedures, SOPs, and approved protocols in cGMP manufacturing environment
    • Prepare required reagents, solutions, and buffers according to SOPs and approved protocols
    • Maintains aseptic clean room environments to comply with current Good Manufacturing Practices (cGMPs) and Standard Operating Procedures (SOPs)
    • Keeps detailed documentation in compliance with SOPs and Good Documentation Practice
    • Operate and maintain cell culture laboratory equipment for production; e.g. Biosafety cabinets, incubators, centrifuges etc.
    • Maintain supplies and reagents inventories, and order as needed
    • Write and/or revise SOPs, protocols, reports, and other required documentation
    • Provide support for commissioning and validation activities in addition to other facility start-up activities, as needed
    • Collaborate with cross-functional teams i.e., Quality, Facilities, Product Development, and Analytical Technologies
    • Perform additional job related duties as required

    Requirements

    • Bachelor/Associate Degree in Biology/Chemistry/Life Sciences or related field, or Biotech certificate.
    • 2+ years relevant cGMP manufacturing experience in Pharmaceutical/Biotech industry is preferred
    • Aseptic manufacturing experience is highly desired
    • Mammalian cell culture experience is preferred
    • Experience writing standard operating procedures and other cGMP documentation is preferred
    • Experience writing investigation, deviation and change control documentation is preferred
    • Ability to understand, apply, and evaluate basic biology and scientific principles as appropriate for the position
    • Excellent organizational and multi-tasking skills, attention to detail, and the ability to adapt to changing priorities
    • Ability to identify and elevate processing issues and support solutions
    • Must be able to work weekends and holidays as required
    • Excellent oral and written communications skills and a collegial personality
    • Thrives and succeeds in a team-oriented environment
    • Computer literacy including fluency with Microsoft Word, Excel, Outlook
    • Participate at appropriate department meetings
    • Ability to sit or stand for long periods of time, and ability to lift 25-30 lbs

    Disclaimer:

    The above statements are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time, as needed.

    Please send your resume to our hiring department (cover letter optional) email jobs@asteriasbio.com

    Apply using webmail: Gmail / AOL / Yahoo / Outlook

  •   
    Process Development Technician
    Full Time
    Fremont, CA

    Title: Process Development Technician

    Department: Product Development (PD)

    Reports to: Senior Process Development Scientist

    Position Description:

    The Process Development Technician position will support technology and process development efforts for our human stem cell-derived therapies within Asterias. The Process Development team facilitates testing and implementation of future production processes and technologies and is responsible for process conversions and technology integration to allow scale appropriate process transfer for either in-house or out-sourced production. This position will provide support for collaborations with Research, Production, Bioengineering, and Analytical Technologies to foster effective communication, technology transfer, and achievement of corporate goals. The position will perform work for PD and Research staff to enable process improvements targets and optimize process implementation. This position will be responsible for and participate in the daily operations of research and development laboratories.

    Summary of Essential Job Functions:

    • Perform hands-on execution of experiments directed towards process development and optimization using undifferentiated human embryonic stem cells: including but not limited to:

      • Preparation of cell culture raw materials
      • Monitoring, sampling and documenting of cell culture performance
      • Regular passaging of cells
      • Thawing and freezing cell lines and processing samples
    • Perform process sampling to monitor process development activities and optimization through adequate sample archives.
    • Compile and maintain complete and accurate laboratory documentation and critical data in electronic files in a highly organized manner.
    • Interact with Facilities to manage and troubleshoot cell culture equipment including calibration, certification, and repair.
    • Maintain lab operations (supply restocking, ordering and inventory, schedule cleaning services and record keeping for equipment-use logs).
    • Support drafting of technical documents (protocols, technical reports, summaries, process investigations, SOPs and batch records) as required.
    • Collaborate with cross-functional teams i.e., Research, Quality, Production, and Analytical Technologies.

    Minimum Requirements

    • BS in Biology, Biochemistry or related field.
    • Laboratory research experience (minimum of 3-6 months in an academic or industry lab) desired.
    • Excellent communication abilities (verbal, written, interpersonal).
    • Excellent time management and organizational skills (schedules, timelines, task prioritization), with the ability to adapt to changing priorities.
    • Excellent multi-tasking and problem-solving skills; solution-oriented; self-motivated.
    • Experience in aseptic mammalian cell culture handling experience desired.
    • Experience in cell-based therapy culture and/or development desired.
    • A record of strong laboratory and critical thinking skills desired.
    • Ability to work an alternative schedule (day shift encompassing Saturday and Sunday).
    • Flexible in regards to holiday work schedule.
    • Thrive and succeed in a team-oriented entrepreneurial environment.

    Abilities Required

    • Computer literacy with standard corporate (MS) required.

    Disclaimer:

    The above statements are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time, as needed.

    Please send your resume to our hiring department (cover letter optional) email jobs@asteriasbio.com

    Apply using webmail: Gmail / AOL / Yahoo / Outlook

  •   
    Process Development Associate
    Full Time
    Fremont, CA

    Title: Process Development Associate

    Department: Product Development (PD)

    Reports to: Associate Director, Bioprocess Engineering

    Position Description:

    The Process Development Associate position will work on technology and process development efforts for our human stem cell-derived therapies within Asterias. The Process Development team facilitates testing and implementation of future production processes and technologies and is responsible for process conversions and technology integration to allow scale appropriate process transfer for either in-house or out-sourced production. This position will support collaborations with Research, Production, Bioengineering, and Analytical Technologies to foster effective communication, technology transfer, and achievement of corporate goals. The position will work alongside PD and Research staff to support process improvements targets and optimize process implementation. This position will participate in the daily operations of development laboratories.

    Summary of Essential Job Functions:

    • Assists in experiments directed towards process development and optimization using undifferentiated human embryonic stem cells: including but not limited to preparation of cell culture raw materials, monitoring, sampling and documenting of cell culture performance, regular passaging of cells, thawing and freezing cell lines, cell banking and processing samples.
    • Generate, manage, evaluate, and maintain complete and accurate laboratory documentation and critical data in electronic files in a highly organized manner.
    • Operates and troubleshoots cell culture equipment.
    • Maintains lab operations.
    • Draft and review technical documents (protocols, technical reports, summaries, process investigations, SOPs and batch records).
    • Collaborate with cross-functional teams i.e., Research, Quality, Production, and Analytical Technologies.
    • Perform process sampling to monitor process development activities and optimization through adequate sample archives.

    Minimum Requirements

    • BS in Biology, Biochemistry or related field, with 2 years’ experience in industry or academic lab required.
    • Experience in aseptic mammalian cell culture handling experience required.
    • Experience in cell-based therapy culture and/or development desired.
    • A proven record of strong laboratory and critical thinking skills required.
    • Excellent communication abilities (verbal, written, interpersonal).
    • Excellent time management and organizational skills (schedules, timelines, task prioritization), with the ability to adapt to changing priorities.
    • Excellent multi-tasking and problem-solving skills; solution-oriented; self-motivated.
    • Flexible in regards to weekends and holiday work schedule.
    • Occasional weekend work expected.
    • Thrive and succeed in a team-oriented entrepreneurial environment.

    Abilities Required

    • Computer literacy with standard corporate (MS) required.

    Disclaimer:

    The above statements are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time, as needed.

    Please send your resume to our hiring department (cover letter optional) email jobs@asteriasbio.com

    Apply using webmail: Gmail / AOL / Yahoo / Outlook

Asterias Biotherapeutics Tel: (510) 456-3800